Biomarkers of 5-FU response in colon cancer
نویسندگان
چکیده
منابع مشابه
Investigation of the Effects of Vitamin C on Resistance to 5-FU in Colon Cancer Cells Line HT29
Introduction: There is growing evidence about the use of antioxidants to reduce the side effects of chemotherapy and cancer drug resistance. Therefore, this study aimed to use vitamin C as an antioxidant and determine its effect on drug resistance in HT29 cells. Materials & Methods: During this case-control study, HT29 cells were first cultured and evaluated by MTT assay for cell death in th...
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Adjuvant chemotherapy has been shown to alter the natural history of resected colon cancer. Two regimens (fluorouracil [5-FU] plus leucovorin and 5-FU plus levamisole) have been found to prolong disease-free survival and overall survival in affected patients. Previous comparisons of these two regimens indicate that 5-FU plus leucovorin may offer a small disease-free survival and overall surviva...
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S-1, a novel oral fluoropyrimidine, is increasingly used for the treatment of human cancer including gastrointestinal carcinomas. Using the 5-FU resistant DLD-1/FU human colon cancer cell xenografts, the present study investigated whether S-1 enhances the therapeutic efficacy of radiation and if so what are the underlying mechanisms. Nude mice bearing tumor xenografts were treated with radiatio...
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Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e. neutropenia, diarrhea or cardiotoxicity, the knowledge of 5-FU serum levels might help to attribute these sid...
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Correspondence to Dr. Silke Cameron, MD Department of Gastroenterology and Endocrinology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany silke.cameron@med. uni-goettingen.de
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2011
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.11.8.15109